Neurocognitive impacts of arbovirus infections.
Marion CléPatrick EldinLaurence BriantAnnie LannuzelYannick SimoninPhilippe Van de PerreAndré CabiéSara SalinasPublished in: Journal of neuroinflammation (2020)
Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, some arboviral infections can be associated with important neuroinflammation that can trigger neurological disorders including encephalitis, paralysis, ophthalmological impairments, or developmental defects, which in some cases, can lead to long-term defects of the central nervous system (CNS). This is well illustrated in Zika virus-associated congenital brain malformations but also in West Nile virus-induced synaptic dysfunctions that can last well beyond infection and lead to cognitive deficits. Here, we summarize clinical and mechanistic data reporting on cognitive disturbances triggered by arboviral infections, which may highlight growing public health issues spanning the five continents.
Keyphrases
- zika virus
- public health
- aedes aegypti
- dengue virus
- drug induced
- liver failure
- cerebral ischemia
- traumatic brain injury
- electronic health record
- resting state
- intensive care unit
- machine learning
- big data
- blood brain barrier
- high glucose
- brain injury
- diabetic rats
- multiple sclerosis
- subarachnoid hemorrhage
- cerebrospinal fluid
- lps induced
- functional connectivity
- acute respiratory distress syndrome
- stress induced