Access to 6-hydroxy indolizines and related imidazo[1,5- a ]pyridines through the S N 2 substitution/condensation/tautomerization cascade process.

A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters. Their optical properties were also evaluated.