Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets.

Kristine HoleSilje K LorentsenKaroline L NordbyMarie SlettvikIda Tg SørumEspen Molden Tore Haslemo

Published in: European journal of clinical pharmacology (2024)

The effect of lamotrigine in reducing quetiapine concentration is only significant for patients using quetiapine IR tablets who are treated with lamotrigine doses > 200 mg/day. Because of high variability in the interaction effect, TDM of quetiapine should be recommended during co-prescription of high-dose lamotrigine.

Keyphrases

end stage renal disease
newly diagnosed
high dose
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
low dose