CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

Luke W ThomasJenna M StephenCinzia EspositoSimon HoerRobin AntrobusAfshan AhmedHasan Al-HabibMargaret Ashcroft

Published in: Cancer & metabolism (2019)

Our study highlights an important role for CHCHD4 in regulating tumour cell metabolism and reveals that CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain and CI biology.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
single cell
signaling pathway
cell therapy
respiratory tract
pi k akt