Stability and plasticity of Regulatory T cells in health and disease.

The mechanisms that negatively regulate inflammation upon a pathogenic stimulus are crucial for the maintenance of tissue integrity and organ function. T regulatory cells are one of the main drivers in controlling inflammation. The ability of Treg cells to adapt to different inflammatory cues and suppress inflammation is one of the relevant features of Tregs. During this process, Tregs express different transcription factors associated with the counterparts Th helper cells, including Tbx21, GATA-3, Bcl6 and Rorc. The acquisition of this transcription factor helps the Treg to suppress and migrate to the different inflamed tissues. Additionally, the Tregs have different mechanisms that preserve stability while acquiring a particular Treg subtype. This review focuses on describing Tregs subtypes and the mechanisms that maintain their identity in health and diseases.