[18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates.
Matthew ZammitYunlong TaoMiles E OlsenJeanette MetzgerScott C VermilyeaKathryn BjornsonMaxim SlesarevWalter F BlockKerri FuchsSean PhillipsViktorya BondarenkoSu-Chun ZhangMarina E EmborgBradley T ChristianPublished in: EJNMMI research (2020)
These findings reveal that [18F]FEPPA PET is an effective marker for detecting increased CD68-positive microglial/macrophage activation and demonstrates sufficient sensitivity to detect changes in neuroinflammation in vivo following allogeneic cell engraftment.
Keyphrases
- pet imaging
- lipopolysaccharide induced
- lps induced
- inflammatory response
- single cell
- positron emission tomography
- adipose tissue
- traumatic brain injury
- stem cell transplantation
- neuropathic pain
- hematopoietic stem cell
- cognitive impairment
- bone marrow
- nk cells
- cerebral ischemia
- computed tomography
- genome wide
- pet ct
- cell therapy
- mesenchymal stem cells
- gene expression
- spinal cord injury
- stem cells
- blood brain barrier
- high dose