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[18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates.

Matthew ZammitYunlong TaoMiles E OlsenJeanette MetzgerScott C VermilyeaKathryn BjornsonMaxim SlesarevWalter F BlockKerri FuchsSean PhillipsViktorya BondarenkoSu-Chun ZhangMarina E EmborgBradley T Christian
Published in: EJNMMI research (2020)
These findings reveal that [18F]FEPPA PET is an effective marker for detecting increased CD68-positive microglial/macrophage activation and demonstrates sufficient sensitivity to detect changes in neuroinflammation in vivo following allogeneic cell engraftment.
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