Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort.
John R LozadaThais BasiliFresia ParejaBarbara AlemarArnaud Da Cruz PaulaRodrigo Gularte-MéridaDilip D GiriPatricia QuerzoliGábor CserniEmad A RakhaMaria P FoschiniJorge Sergio Reis-FilhoEdi BrogiBritta WeigeltFelipe C GeyerPublished in: Histopathology (2018)
We validated the presence of IDH2 R172 hotspot mutations and PIK3CA hotspot mutations in 100% and 67% BPTCs tested, respectively, and documented absence of IDH2 R172 mutations in SPCs. These findings confirm the genotypical-phenotypical correlation reported previously in BPTC, which constitutes an entity distinct from conventional SPC.