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Molecular Targeting of HuR Oncoprotein Suppresses MITF and Induces Apoptosis in Melanoma Cells.

Rebaz AhmedRanganayaki MuralidharanAkhil SrivastavaSarah E JohnstonYan D ZhaoSuhendan EkmekciogluAnupama MunshiRajagopal Ramesh
Published in: Cancers (2021)
HuR-NP exhibited antitumor activity in melanoma cells independent of their oncogenic B-RAF mutational status. Additionally, combinatorial therapy incorporating MEK inhibitor holds promise in overriding MITF-mediated drug resistance in melanoma.
Keyphrases
  • binding protein
  • signaling pathway
  • cancer therapy
  • big data
  • skin cancer
  • stem cells
  • single molecule
  • machine learning
  • mesenchymal stem cells
  • bone marrow
  • deep learning
  • basal cell carcinoma