T1AM Attenuates the Hypoxia/Reoxygenation-Induced Necroptosis of H9C2 Cardiomyocytes via RIPK1/RIPK3 Pathway.

Bo WeiHanbing ZhaoBailong HuLujun DaiGuoning ZhangLili MoNiwen HuangChangchao ZouBei ZhangHaiyan ZhouDa-Nan Liu Xingde Liu

Published in: BioMed research international (2022)

Pretreatment with T1AM could alleviate cardiomyocytes' H/R injury and inhibit necroptosis of cardiomyocytes, which might exert a protective function upon activation of the RIPK1/RIPK3 pathway.

Keyphrases

high glucose
endothelial cells
diabetic rats
signaling pathway
endoplasmic reticulum stress