Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis.
Tao LiYan XiongJian LiXin TangYutong ZhongZhigang TangQiuping ZhangYubin LuoPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
This study provides overall protein and gene profiles of PVNS and identifies the crucial role of TGFβ in synovial invasion pathology. Exploring the related molecular mechanism may also reveal a new strategy or target for PVNS therapy.
Keyphrases
- transforming growth factor
- genome wide
- epithelial mesenchymal transition
- cell migration
- copy number
- dna methylation
- protein protein
- high resolution
- genome wide identification
- amino acid
- binding protein
- stem cells
- bone marrow
- mesenchymal stem cells
- mass spectrometry
- transcription factor
- cell therapy
- replacement therapy