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High interobserver variability and frequent overdiagnosis of dysplasia in fundic gland polyps can be improved by detecting atypia on the surface epithelium and an abrupt transition to non-neoplastic cells.

Christine E OrrDebra BeneckJose JessurunLihui QinKathrin TyryshkinRhonda K YantissYao-Tseng Chen
Published in: Histopathology (2021)
There is high interobserver variability and a tendency to overdiagnose LGD in FGPs. Strict criteria requiring both surface atypia and abrupt transition for LGD in FGPs result in low interobserver variability.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • cell proliferation