Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia.
Adeline DollySarah A PötgensMorgane M ThibautAudrey M NeyrinckGabriela S de CastroChloé GalbertCamille LefevreElisabeth WyartSilvio P GomesDaniela C GonçalvesNicolas LanthierPamela BaldinJoshua R HuotAndrea BonettoMarilia SeelaenderNathalie M DelzenneHarry SokolLaure B BindelsPublished in: Journal of cachexia, sarcopenia and muscle (2023)
With this set of studies, we demonstrate that impairment of AHR signalling contributes to hepatic inflammatory and metabolic disorders characterizing cancer cachexia, paving the way for innovative therapeutic strategies in this context.