In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration.
Jessica P AnandKelsey E KochanAnthony F NastaseDeanna MontgomeryNicholas W GriggsJohn R TraynorHenry I MosbergEmily M JutkiewiczPublished in: British journal of pharmacology (2018)
AAH8 may be a better alternative than traditional opioid analgesics, producing antinociception with less development of tolerance and dependence and may be less rewarding than morphine.