CD4+CD25Hi FoxP3+ regulatory T cells in long-term cardiac xenotransplantation.
Avneesh K SinghJoshua L ChanCaleb N SeaveyPhilip C CorcoranRobert F HoytBilleta G T LewisMarvin L ThomasDavid L AyaresKeith A HorvathMuhammad M MohiuddinPublished in: Xenotransplantation (2017)
Our results suggest that regulatory T (Treg) cells may contribute to preventing or delaying xenograft rejection by controlling the activation and expansion of donor-reactive T cells, thereby masking the antidonor immune response, leading to long-term survival of cardiac xenografts.