Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review.
Francisco Cezar Aquino de MoraesLucca Dal MoroFernando Rocha PessoaEllen Sabrinna Dos Remédios PassosRaul Antônio Lopes Silva CamposDilma do Socorro Moraes de SouzaDanielle FeioRommel Mario Rodríguez BurbanoMarianne Rodrigues FernandesNey Pereira Carneiro Dos SantosPublished in: Cancers (2023)
Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence in males (76.9%, n = 10). The average time for neoplasm development was 4.4 years (54.07 months). The most prevalent model was Medtronic (38.4%, n = 5), with titanium (83.3%) being the most common metal composition. Chemotherapy was the most performed procedure among patients (38.4%), followed by radiation therapy (38.4%) and surgical tumor resection (30.7%). Six analyzed cases (46.1%) resulted in death, and four patients (30.7%) achieved a cure. Patients with pacemakers should be routinely evaluated for the occurrence of malignant tumors at the site of device implantation.
Keyphrases
- radiation therapy
- vena cava
- left ventricular
- induced apoptosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- public health
- signaling pathway
- risk assessment
- risk factors
- locally advanced
- social media
- papillary thyroid
- squamous cell carcinoma
- cell cycle arrest
- health information
- minimally invasive
- endoplasmic reticulum stress
- machine learning
- oxidative stress
- young adults
- patient reported
- rare case
- rectal cancer
- pi k akt
- chemotherapy induced