Plasma proteomic analysis to identify potential biomarkers of histologic chorioamnionitis in women with preterm premature rupture of membranes.

Ji Eun LeeKisoon DanHyeon Ji KimYu Mi KimKyo Hoon Park

Published in: PloS one (2022)

Plasma C4A, SAA4, and CRP were identified as potential biomarkers for detecting HCA in women with PPROM, based on targeted and shotgun proteomic analyses, showing good accuracy when used as a combined dual-biomarker panel (C4A and SAA4). Nevertheless, ELISA validation of these proteins, except for CRP, may not yield clinically useful markers for predicting HCA.

Keyphrases

preterm birth
cancer therapy
low birth weight
gestational age
drug delivery