Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L.
Abbie FrancisE BosioS F StoneD M FatovichG ArendtsY NagreeS P J MacdonaldH MitenkoM RajeeS BurrowsS G A BrownPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
These results provide compelling evidence for the involvement of neutrophils during acute human anaphylaxis, suggesting they are activated early in the reaction, regardless of mast cell activation. This important finding increases our understanding of the basic mechanisms of anaphylaxis, a necessary precursor to improving treatment and prevention.