Asperolide A prevents bone metastatic breast cancer via the PI3K/AKT/mTOR/c-Fos/NFATc1 signaling pathway.

Wenli JiangYoulutuziayi RixiatiHao HuangYiJun ShiCaiguo HuangBinghua Jiao

Published in: Cancer medicine (2020)

Our study demonstrated that AA suppressed bone metastatic breast cancer. These findings indicate AA as a potential, novel curative drug candidate for patients with bone metastatic breast cancer.

Keyphrases

metastatic breast cancer
bone mineral density
signaling pathway
soft tissue
bone loss
bone regeneration
postmenopausal women
pi k akt
epithelial mesenchymal transition
body composition
emergency department
mouse model
oxidative stress
climate change
prognostic factors
drug induced