Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs.

Tiina FöhrKatja WallerAnne ViljanenRiikka SanchezMiina OllikainenTaina RantanenJaakko KaprioElina Sillanpää

Published in: Clinical epigenetics (2021)

In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences. Smoking, which is known to alter DNAm levels and is built into the DNAm GrimAge algorithm, attenuated the association between epigenetic aging and mortality risk.

Keyphrases

nk cells
dna methylation
genome wide
cardiovascular events
gene expression
risk factors
machine learning
copy number
deep learning
smoking cessation
cardiovascular disease