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Naringin@Metal-Organic Framework as a Multifunctional Bioplatform.

Xueying GeFangchao JiangMinghui WangMeng ChenYiming LiJoshua PhippsJianfeng CaiJin XieJane OngViktor DubovoyJames G MastersLong PanShengqian Ma
Published in: ACS applied materials & interfaces (2022)
Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal-organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.
Keyphrases
  • metal organic framework
  • high dose
  • endothelial cells
  • signaling pathway
  • oxidative stress
  • emergency department
  • drug delivery
  • mental health
  • gram negative
  • multidrug resistant
  • bone marrow
  • cancer therapy
  • adverse drug