Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression.

Goutam ChakrabortyJoshua ArmeniaYing Z MazzuSubhiksha NandakumarKonrad H Stopsack Mohammad O Atiq Kazumasa KomuraLina JehaneRahim HiraniKalyani ChadalavadaYuki YoshikawaNabeela A KhanYu ChenWassim AbidaLorelei A MucciGwo-Shu Mary LeeGouri J NanjangudPhilip W Kantoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our findings suggest that early identification of this aggressive form of prostate cancer offers potential for improved outcomes with early introduction of PARP inhibitor-based therapy.See related commentary by Mandigo and Knudsen, p. 1784.

Keyphrases

prostate cancer
radical prostatectomy
dna damage
dna repair
bone marrow
risk assessment
oxidative stress
human health
adipose tissue