Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances.

Maria MastrangelopoulouMantas GrigalaviciusTine H RaabeEllen SkarpenPetras JuzenasQian PengKristian BergTheodossis A Theodossiou

Published in: Cancer reports (Hoboken, N.J.) (2020)

This study demonstrates the heterogeneity in the cellular response to 5-ALA-PDT and identifies biomarkers that may be used to predict treatment outcome. The study also provides preliminary findings on the potential of inhibiting specific molecular targets to overcome inherent resistances to 5-ALA-PDT.

Keyphrases

photodynamic therapy
signaling pathway
genome wide
gene expression
risk assessment
human health