Liver Steatosis is Prevalent in Lean People With HIV and Associated With Exposure to Antiretroviral Treatment-A Cross-sectional Study.
Louise E van EekerenNadira VadaqWilhelm A J W VosMarc J T BlaauwAlbert L GroenendijkJan van LunzenJanneke E StalenhoefMarvin A H BerrevoetsAnnelies VerbonGert WeijersMihai G NeteaAndré J A M van der VenQuirijn de MastLeo A B JoostenEric T T L TjwaPublished in: Open forum infectious diseases (2024)
Liver steatosis was highly prevalent, affecting approximately one-fifth of lean PHIV and half of overweight/obese PHIV. Fibrosis was observed in a minority. Both steatosis and fibrosis were associated with traditional metabolic risk factors. In addition, (prior) exposure to specific antiretroviral drugs was associated liver steatosis in lean, but not in overweight/obese PHIV. Implementing increased screening protocols could enhance the identification of steatotic liver disease in lean PHIV.
Keyphrases
- insulin resistance
- weight loss
- hiv infected
- high fat diet
- hiv positive
- human immunodeficiency virus
- adipose tissue
- risk factors
- high fat diet induced
- hiv aids
- bone mineral density
- antiretroviral therapy
- metabolic syndrome
- physical activity
- type diabetes
- bariatric surgery
- hiv infected patients
- men who have sex with men
- weight gain
- hepatitis c virus
- obese patients
- skeletal muscle
- hiv testing
- south africa
- quality improvement
- body composition
- combination therapy
- smoking cessation
- liver fibrosis
- replacement therapy