Analysis of CDK12 alterations in a pan-cancer database.

Elizabeth PanAngelo CabalJuan F Javier-DesLogesDevin PatelJustine PanianSuzanna LeeJustin ShayaTaylor NonatoXiaojun XuTyler StewartBrent RoseAhmed ShabaikEzra CohenRazelle KurzrockPablo TamayoRana R McKay

Published in: Cancer medicine (2021)

CDK12 alterations are rare events across hematologic and solid tumor malignancies. They represent a clinically distinct molecular cancer subtype which may have increased responsiveness to checkpoint inhibition. Prospective studies are warranted to investigate checkpoint inhibition in CDK12-altered tumors.

Keyphrases

cell cycle
papillary thyroid
dna damage
squamous cell
cell proliferation
squamous cell carcinoma
lymph node metastasis
emergency department
oxidative stress
single molecule
case control
electronic health record