Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants.

Priscila Silva FrancoPaula Suellen Guimarães GoisThádia Evelyn de AraújoRafaela José da SilvaBellisa de Freitas BarbosaAngelica de Oliveira GomesFrancesca IettaLara Affonso Dos SantosMaria Célia Dos SantosJosé Roberto MineoEloisa Amalia Vieira Ferro

Published in: Journal of biomedical science (2019)

Azithromycin treatment was effective against T. gondii Brazilian strains compared with conventional treatment. Also, the TgChBrUD1 strain replicated more in villi and modulated important cytokines involved in parasite control, showing that different strains use different strategies to evade the host immune response and ensure their survival.

Keyphrases

toxoplasma gondii
escherichia coli
immune response
endothelial cells
inflammatory response
dendritic cells
toll like receptor
induced pluripotent stem cells
replacement therapy