Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential.

Fibi MeshrkeyKelly M ScheulinChristopher M LittlejohnJoshua StabachBibhuti SaikiaVedant ThoratYimin HuangThomas LaFramboiseEdward J LesnefskyRaj R RaoFranklin D WestShilpa Iyer

Published in: Stem cell research & therapy (2023)

Overall, the hiPSCs exhibited variable mitochondrial dysfunction that may alter their differentiation potential and provide key insights into clinically relevant developmental perturbations.

Keyphrases

induced pluripotent stem cells
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
oxidative stress
prognostic factors
peritoneal dialysis