Tracking and Cumulative Lifetime Exposure to IGF-I in 6,459 Healthy Individuals and in SGA Children Treated with GH.

Anna Sophie L Kjaer Rikke Beck Jensen Jørgen Holm Petersen Allan Linneberg Line Lund Kårhus Louise Scheutz Henriksen Trine Holm Johannsen Katharina M Main Andrew R Hoffman Anders Juul

Published in: The Journal of clinical endocrinology and metabolism (2022)

Since IGF-I and IGFBP-3 levels track throughout life, a single measurement reliably reflects lifetime exposure. GH therapy increased the lifetime exposure to IGF-I only slightly and it remained below the average lifetime exposure in the reference population.

Keyphrases

growth hormone
pi k akt
binding protein
young adults
mesenchymal stem cells