Mitral annular disjunction and its progression during childhood in Marfan syndrome.
Tam T DoanAlejandra Iturralde ChavezSantiago O ValdesJustin D WeigandJames C WilkinsonAnitha ParthibanSara B StephensRicardo H PignatelliShaine A MorrisPublished in: European heart journal. Cardiovascular Imaging (2024)
MAD was common in pediatric MFS and was associated with aortic root dilation. MAD detection by echocardiography and CMR was highly reliable, suggesting that routine assessment in MFS is feasible. MAD was present in neonates and progressed over time but remained constant when indexing by height. Further studies are needed to evaluate MAD as a biomarker for clinical outcomes in pediatric MFS.
Keyphrases
- left ventricular
- mitral valve
- body mass index
- computed tomography
- aortic valve
- childhood cancer
- clinical practice
- left atrial
- aortic dissection
- heart failure
- case report
- physical activity
- low birth weight
- aortic stenosis
- loop mediated isothermal amplification
- early life
- label free
- coronary artery disease
- ejection fraction