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Novel cationic meso -CF 3 BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria.

Wen-Jing ShiJinrong YangYong-Feng WeiXiao-Tong LiXu-Hui YanYuxuan WangHuaxiang LengLiyao ZhengJin-Wu Yan
Published in: Chemical communications (Cambridge, England) (2022)
Two novel meso -CF 3 BODIPY-based fluorescent rotors have been rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence "turn-on" effect, attributed to the special restricted rotation of meso -CF 3 group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibits good mitochondrial localization and AIE property.
Keyphrases
  • living cells
  • fluorescent probe
  • cystic fibrosis
  • single molecule
  • high resolution
  • oxidative stress
  • cell death
  • reactive oxygen species
  • mass spectrometry
  • fluorescence imaging