Synthesis and Biological Activity of the Pyridine-hexacyclic-steroid Derivative on a Heart Failure Model.

Figueroa-Valverde LauroLópez-Ramos MariaDíaz-Cedillo FranciscoRosas-Nexticapa MarcelaMateu-Armad Maria VirginiaAlvarez-Ramirez MagdalenaLopez-Gutierrez TomasArakachi-Cruz Idalia

Published in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2022)

It is noteworthy that positive inotropic activity produced by this steroid-pyridine derivative involves a different molecular mechanism compared to other positive inotropic drugs. Therefore, this steroid could be a good candidate for the treatment of heart failure.

Keyphrases

heart failure
left ventricular
atrial fibrillation
cardiac resynchronization therapy
acute heart failure
drug induced
smoking cessation