Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.
Duale AhmedDavid RoyEdana CassolPublished in: Mediators of inflammation (2018)
With the advent of antiretroviral therapy (ART), HIV-infected individuals are now living longer and healthier lives. However, ART does not completely restore health and treated individuals are experiencing increased rates of noncommunicable diseases such as dyslipidemia, insulin resistance, type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. While it is well known that persistent immune activation and inflammation contribute to the development of these comorbid diseases, the mechanisms underlying this chronic activation remain incompletely understood. In this review, we will discuss emerging evidence that suggests that alterations in cellular metabolism may play a central role in driving this immune dysfunction in HIV patients on ART.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- type diabetes
- end stage renal disease
- cardiovascular disease
- insulin resistance
- newly diagnosed
- oxidative stress
- ejection fraction
- chronic kidney disease
- healthcare
- peritoneal dialysis
- prognostic factors
- mental health
- skeletal muscle
- hepatitis c virus
- adipose tissue
- patient reported outcomes
- polycystic ovary syndrome
- social media
- climate change
- south africa
- liver fibrosis