GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury.

Tingting LvYu ZhangXingZhao JiShengnan SunLi XuWeixia MaYi LiuQiang Wan

Published in: Journal of translational medicine (2022)

In sum, these data demonstrated an unrecognized regulating mechanism of GCN5L1 on TFAM acetylation and its intracellular trafficking, and a potential intervening target for AKI associated mitochondrial disorders as well.

Keyphrases

oxidative stress
acute kidney injury
histone deacetylase
electronic health record
big data
reactive oxygen species
machine learning
risk assessment
deep learning
artificial intelligence