Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling.

Baojian ZhangChao SunYaozhong LiuFan BaiTao TuQi Ming Liu

Published in: Oxidative medicine and cellular longevity (2022)

These results demonstrated a great therapeutic efficacy of miR-27b-3p overexpression in hypoxic CMEC-derived exosomes in preventing the development of myocardial damage post I/R injury through inhibiting Foxo1/GSDMD signaling-induced oxidative stress and pyroptosis.

Keyphrases

signaling pathway
left ventricular
ischemia reperfusion injury
oxidative stress
transcription factor
endothelial cells
nlrp inflammasome
pi k akt
mesenchymal stem cells
stem cells
cell proliferation
hydrogen peroxide
nitric oxide
vascular endothelial growth factor
atrial fibrillation