Surveillance Improves Outcomes for Carriers of SDHB Pathogenic Variants: A Multicenter Study.

Dahlia F DavidoffDiana E BennMichael FieldAshley CrookBruce G RobinsonKatherine TuckerRichard De Abreu LourencoJohn R BurgessRoderick John Clifton-Bligh

Published in: The Journal of clinical endocrinology and metabolism (2022)

SDHB carriers with s-d tumors had smaller tumors, reduced risk of metastatic disease, and lower mortality than probands. Our results suggest that SDHB PV carriers should undertake surveillance to improve clinical outcomes.

Keyphrases

public health
small cell lung cancer
cardiovascular events
copy number
risk factors
type diabetes
dna methylation
gene expression
insulin resistance