Weight regain, but not weight loss exacerbates hepatic fibrosis during multiple weight cycling events in male mice.
Chun-Hsien ChiangTing-Rui ZhangPu-Sheng HsuShau-Ping LinChing-Yi ChenPublished in: European journal of nutrition (2024)
Weight cycling ending in weight gain exacerbated hepatic fibrosis, potentially by inducing apoptosis or disrupting mitochondrial homeostasis. Conversely, weight cycling ending in weight loss demonstrated beneficial effects on hepatic health.
Keyphrases
- weight loss
- weight gain
- bariatric surgery
- gastric bypass
- roux en y gastric bypass
- body mass index
- birth weight
- oxidative stress
- high intensity
- glycemic control
- healthcare
- public health
- physical activity
- obese patients
- endoplasmic reticulum stress
- type diabetes
- skeletal muscle
- adipose tissue
- liver fibrosis
- preterm birth
- insulin resistance
- health promotion