Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Natanja OosteromPieter H GriffioenMarissa A H den HoedRob PietersRobert de JongeWim J E TissingMarry M van den Heuvel-EibrinkSandra G HeilPublished in: PloS one (2018)
This was the first study that assessed DNA methylation in relation to MTX-induced oral mucositis in children with ALL. Although global methylation markers did change during methotrexate therapy, methylation status was not associated with developing oral mucositis.