Preparation of Thioaminals in Water.
Lídia A S CavacaRafael F A GomesCarlos A M AfonsoPublished in: Molecules (Basel, Switzerland) (2022)
The presence of sulfur-carbon bonds is transversal to several areas of chemistry, e.g., drug discovery, materials, and chemical biology. However, a lack of efficient and sustainable procedures for the preparation of thioaminals, the N,S -analogues of O,O -acetals, contributes to this functional group often being overlooked by the scientific community. In this work is described the formation of thioaminals in water promoted by copper(II) triflate.