Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts.
Beatrice Anna BruggerLena NeuperJacqueline GuettlerDésirée ForstnerStefan WernitznigDaniel KummerFreya LyssyJulia FeichtingerJulian KrappingerAmin El-HeliebiLilli BonstinglGerit MoserGiovanny Rodriguez-BlancoOlaf A BachkönigBenjamin GottschalkMichael GruberOlivia NonnFlorian HerseStefan VerlohrenHans-Georg FrankNirav BarapatreCornelia KampferHerbert FluhrGernot DesoyeMartin GausterPublished in: Cell & bioscience (2023)
Our study suggests that onset of uteroplacental blood flow is accompanied by a shift from a predominant glycolytic- to an alternative amino acid converting metabolism in the villous trophoblast. Rheological changes with excessive fluidic shear stress at the placental surface, may disrupt this alternative amino acid pathway in the syncytiotrophoblast and could contribute to intrauterine growth restriction.