Galectin 3-binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1 (TGF-β1) availability and inhibits hepatocarcinogenesis.

Dae-Hwan KimMinjeong SungMyong-Suk ParkEun-Gene SunSumin YoonKyung Hyun YooKamalakannan RadhakrishnanSung Yun JungWoo-Kyun BaeSang-Hee ChoIk Joo Chung

Published in: Cancer communications (London, England) (2024)

LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TGF-β1 signaling pathway, making it a promising therapeutic target in TGF-β1-related diseases.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
binding protein
pi k akt
oxidative stress
induced apoptosis