Associations between vitamin D status, VDR gene polymorphisms and echocardiographic markers in Polish patients with cardiovascular disease.
Mohamed AbouzidPaweł BurchardtLeonid KaganFranciszek K GłówkaMarta Karaźniewicz-ŁadaPublished in: Future cardiology (2024)
Aim: This work was designed to investigate the associations between vitamin D metabolites, VDR gene polymorphisms and echocardiographic markers in a population of patients with cardiovascular disease. Methods: Echocardiographic markers for 42 patients were determined with tissue Doppler techniques. PCR-restriction fragment length polymorphism analysis identified genetic variants ApaI , TaqI , BsmI and FokI . A validated UHPLC-MS/MS method determined vitamin D metabolites. Results: Patients with the ApaI -GT genotype exhibited a lower pressure gradient across the aortic valve than ApaI -TT carriers. BMI, ApaI -GT, TaqI -TC, aortic arch diameter and maximal pressure gradient were significant univariate predictors of hypertension. Conclusion: A potential link exists between VDR gene polymorphisms and cardiovascular function.
Keyphrases
- ms ms
- ejection fraction
- aortic valve
- cardiovascular disease
- aortic stenosis
- left ventricular
- pulmonary hypertension
- end stage renal disease
- mitral valve
- transcatheter aortic valve replacement
- aortic valve replacement
- left atrial
- transcatheter aortic valve implantation
- newly diagnosed
- chronic kidney disease
- liquid chromatography tandem mass spectrometry
- body mass index
- heart failure
- cardiovascular risk factors
- blood flow
- cardiovascular events
- metabolic syndrome
- human health
- atrial fibrillation
- high intensity
- weight gain
- high resolution
- high resolution mass spectrometry