DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.
Szymon J SzymuraGiovanna M BernalLongtao WuZhongqin ZhangClayton D CrawleyDavid J VocePaige-Ashley CampbellDiana E RanoaRalph R WeichselbaumBakhtiar YaminiPublished in: BMC biology (2020)
These results identify DDX39B, a factor with known functions in mRNA splicing and nuclear export, as an RNA-binding protein that blocks a subset of the inflammatory response. While these findings identify a pathway by which DDX39B promotes sensitization to DNA damaging therapy, the data also reveal a mechanism by which this helicase may act to mitigate autoimmune disease.
Keyphrases
- binding protein
- inflammatory response
- lps induced
- signaling pathway
- lipopolysaccharide induced
- circulating tumor
- multiple sclerosis
- electronic health record
- oxidative stress
- cell free
- toll like receptor
- nucleic acid
- locally advanced
- nuclear factor
- squamous cell carcinoma
- big data
- stem cells
- gene expression
- single cell
- immune response
- radiation therapy
- artificial intelligence
- smoking cessation