HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?

Simone NuessleDaniel SorianoDaniel BoehringerHans MittelviefhausClemens LangeThomas ReinhardLisa AtzrodtClaudia Auw-Haedrich

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

Our study shows that HIF-1α and HIF-2α do not serve as diagnostic or prognostic markers in CIN. ProExC seems to be a potential indicator for CIN, but not a reliable diagnostic marker. However, control specimens occasionally also display a high percentage of ProExC-positive cells and staining over the entire epithelial layer.

Keyphrases

endothelial cells
high grade
cell death
risk assessment
oxidative stress
climate change