CA125: a novel cardiac biomarker for infants with congenital diaphragmatic hernia.
Lukas SchroederFlaminia PugnaloniRamona Dolscheid-PommerichAnnegret GeipelChristoph BergStefan HoldenriederAndreas MuellerFlorian KipfmuellerPublished in: Pediatric research (2022)
CA125 was proven as robust cardiac biomarker in adult cohorts. Information about the utility as a biomarker in neonatal cohorts is lacking. This is the first study analyzing CA125 as a cardiac biomarker in a cohort of infants with congenital diaphragmatic hernia (CDH). CA125 correlates significantly with markers of echocardiographic assessment (PH and ventricular dysfunction) in infants with CDH and helps to identify infants at high risk for ECMO and in-hospital mortality. The results underline the need for the inclusion of cardiac biomarkers in the clinical routine in neonates at risk for cardiopulmonary failure.