Chrysophanol exerts a protective effect against Aβ 25-35 -induced Alzheimer's disease model through regulating the ROS/TXNIP/NLRP3 pathway.
Meng ZhangZhi-Xian DingWei HuangJing LuoShu YeSheng-Lin HuPeng ZhouBiao CaiPublished in: Inflammopharmacology (2023)
-induced AD model mainly by reducing oxidative stress and neuroinflammation, and the mechanism may be related to ROS/TXNIP/NLRP3 signaling pathway.
Keyphrases
- diabetic rats
- oxidative stress
- nlrp inflammasome
- dna damage
- signaling pathway
- high glucose
- cell death
- traumatic brain injury
- drug induced
- ischemia reperfusion injury
- epithelial mesenchymal transition
- cognitive impairment
- brain injury
- endothelial cells
- cell proliferation
- lipopolysaccharide induced
- lps induced
- endoplasmic reticulum stress
- mild cognitive impairment