Effects of tolvaptan in patients with chronic kidney disease and chronic heart failure.
Mari KatsumataNobuhito HirawaKoichiro SumidaMinako KagimotoYosuke EharaYuki OkuyamaMegumi FujitaAkira FujiwaraMayumi KobayashiYusuke KobayashiYuichiro YamamotoSanae SakaKeisuke YatsuTetsuya FujikawaYoshiyuki ToyaGen YasudaKouichi TamuraSatoshi UmemuraPublished in: Clinical and experimental nephrology (2017)
Tolvaptan is effective in increasing diuresis and improved hyponatremia, even in patients with CKD. The baseline urine osmolality, urine volume, and IVCD may be useful predictors for diuretic effects of tolvaptan.