Stacked hexagonal prism of Ag@Ni-MOF-1 as functionalized SERS platform through rational integration of catalytic synthesis of dopamine-quinone at physiological pH with a biomimetic route.

Herein, a novel stacked hexagonal prism, Ag@Ni-MOF-1, was designed and developed as an integrated SERS platform not only for successfully catalyzing the in situ synthesis of DA-quinone under physiological pH, but also for establishing an approach for specific determination of Cys, an important species in the brain related to Alzheimer's disease (AD).