Gene Therapy of Thromboangiitis Obliterans with Growth Factor Plasmid (VEGF165) and Autologous Bone Marrow Cells.
Piotr BarćPawel LubienieckiMaciej AntkiewiczDiana KupczyńskaJan BarćKatarzyna Frączkowska-SiomaTomasz DawiskibaTadeusz DorobiszWojciech SekulaBłażej CzuwaraMałgorzata Małodobra-MazurDagmara BaczyńskaWojciech WitkiewiczJan Paweł SkóraDariusz JanczakPublished in: Biomedicines (2024)
Gene therapy using the VEGF plasmid along with or without bone marrow-derived mononuclear cells administered intramuscularly into an ischemic limb in TAO is a safe and effective therapy.
Keyphrases
- gene therapy
- growth factor
- bone marrow
- induced apoptosis
- cell cycle arrest
- escherichia coli
- mesenchymal stem cells
- vascular endothelial growth factor
- endothelial cells
- crispr cas
- endoplasmic reticulum stress
- stem cells
- cell death
- oxidative stress
- cell therapy
- peripheral blood
- subarachnoid hemorrhage
- blood brain barrier