Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis.
Ye GongYa-Ling ZhangZhen WangHuan-Huan SongYuan-Chu LiuAo-Wei LvLi-Li TianWen-Li ZhuYing FuXiao-Li DingLang-Jun CuiYa-Ping YanPublished in: Journal of neuroinflammation (2020)
Our data provide evidence that TSA can act as a prophylactic agent that reduces NMO-IgG-induced damage in the mouse brain by enhancing the resolution of inflammation by inducing neutrophil apoptosis, and TSA may serve as a promising therapeutic agent for neutrophil-associated inflammatory disorders, such as NMOSD.