A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease.
Elisa Napolitano FerreiraBruna Durães Figueiredo BarrosJorge Estefano de SouzaRenan Valieris AlmeidaGiovana Tardin TorrezanSheila GarciaAna Cristina Victorino KrepischiCelso Abdon Lopes de MelloIsabela Werneck da CunhaClóvis Antonio Lopes PintoFernando Augusto SoaresEmmanuel Dias-NetoAdemar LopesSandro José de SouzaDirce Maria CarraroPublished in: Human genomics (2016)
Overall, our findings revealed genes with potential to be associated with risk assessment and tumorigenesis of this rare type of sarcoma. Additionally, we established a liquid biopsy approach for monitoring patient follow-up based on genomic information that can be similarly adopted for patients diagnosed with a rare tumor.
Keyphrases
- risk assessment
- end stage renal disease
- human health
- single cell
- ejection fraction
- chronic kidney disease
- newly diagnosed
- copy number
- prognostic factors
- case report
- healthcare
- peritoneal dialysis
- genome wide
- cell therapy
- ultrasound guided
- stem cells
- heavy metals
- mesenchymal stem cells
- health information
- ionic liquid
- climate change
- fine needle aspiration