Diagnostic Accuracy of Amyloid versus 18 F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia.
Orit H Lesman-SegevRenaud La JoieLeonardo IaccarinoIryna LobachHoward J RosenSang Won SeoMustafa JanabiSuzanne L BakerLauren EdwardsJulie PhamJohn OlichneyAdam BoxerEric HuangMarilu Gorno-TempiniCharles DeCarliMackenzie HepkerJi-Hye L HwangBruce L MillerSalvatore SpinaLea T GrinbergWilliam W SeeleyWilliam J JagustGil D RabinoviciPublished in: Annals of neurology (2020)
In our sample enriched for younger onset cognitive impairment, PIB-PET had higher sensitivity than FDG-PET for intermediate-high ADNC, with similar specificity. When both modalities are congruent, sensitivity and specificity approach 100%, whereas mixed pathology should be considered when PIB and FDG are incongruent. ANN NEUROL 2021;89:389-401.